Best PEEP trials are dependent on tidal volume

Best PEEP trials are dependent on tidal volume

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Abstract Determining the optimal positive end-expiratory pressure (PEEP) in patients with acute respiratory distress syndrome remains an area of active investigation.Most trials individualizing PEEP optimize one physiologic parameter (e.g., driving pressure) by titrating PEEP while holding here other ventilator settings constant.

Optimal PEEP, however, nacrack.com may depend on the tidal volume, and changing the tidal volume with which a best PEEP trial is performed may lead to different best PEEP settings in the same patient.Trial registration ClinicalTrials.gov, NCT02871102.Registered on 12 August 2016.